منابع مشابه
IBD and IBS based definitions for FST, FIS and FIT
Consider the process FFg in the main text. As we assume that the genes under consideration are neutral, the expected allele frequency for any individual equals to that in the ancestral generation, EE�xxiiiiiiii � = ppiiii . As xxiiiiiiii is an indicator function with values 0 or 1, it further holds that EE�xxiiiiiiii xxiiiiiiii � = ppiiii , and EE�xxiiiiiiii ′xxiiiiiiii � = 0 for ii ≠ ii′. The ...
متن کاملFunctional analysis of human RPS14 null alleles.
Previously we described a large collection of cloned human DNAs that encode chemically defined missense mutations within the ribosomal protein S14 sequence. We determined that biologically inactive (i.e. null) alleles resulted primarily from point mutations targeted to two internal segments of the S14-coding sequence and designated these functionally critical regions as domains B and D. Further...
متن کاملAhr null alleles: distinctive or different?
Two independent laboratories have generated Ahr "null" or "knockout" mice that share some common characteristics but also have distinct phenotypes. In this Commentary, we will discuss our view of the candidate variables that might account for these differences. More importantly, we hope that this discussion can identify important parameters to be assessed by investigators in the process of char...
متن کاملMicrosatellite null alleles and estimation of population differentiation.
Microsatellite null alleles are commonly encountered in population genetics studies, yet little is known about their impact on the estimation of population differentiation. Computer simulations based on the coalescent were used to investigate the evolutionary dynamics of null alleles, their impact on F(ST) and genetic distances, and the efficiency of estimators of null allele frequency. Further...
متن کاملSTR sequence analysis for characterizing normal, variant, and null alleles.
DNA sequence variation is known to exist in and around the repeat region of short tandem repeat (STR) loci used in human identity testing. While the vast majority of STR alleles measured in forensic DNA laboratories worldwide type as "normal" alleles compared with STR kit allelic ladders, a number of variant alleles have been reported. In addition, a sequence difference at a polymerase chain re...
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ژورنال
عنوان ژورنال: Journal of Heredity
سال: 2018
ISSN: 0022-1503,1465-7333
DOI: 10.1093/jhered/esy013